6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine
PU-WS13
CAS: 1454619-14-7
Molecular Formula: C17H20Cl2N6S
6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine - Names and Identifiers
6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine - Physico-chemical Properties
| Molecular Formula | C17H20Cl2N6S |
| Molar Mass | 411.35 |
| Density | 1.47±0.1 g/cm3(Predicted) |
| Boling Point | 617.4±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 40 mg/mL |
| pKa | 10.15±0.29(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| In vitro study | PU-WS13 is a Grp94 inhibitor, with an EC 50 of 0.22 μM. PU-WS13 also slightly suppresses Hsp90α, Hsp90β and Trap-1, with EC 50 s of 27.3, 41.8 and 7.3 μM, respectively. PU-WS13 (2.5-20 μM) shows no toxicity on two nonmalignant cell lines. PU-WS13 (15 μM) disrupts the circular architecture of HER2 at the plasma membrane of SKBr3 cells mediated through Grp94. PU-WS13 inhibits Grp94, and the inhibition induces apoptosis in and reduce the viability of HER2 overexpressing breast cancer cells. |
6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.431 ml | 12.155 ml | 24.31 ml |
| 5 mM | 0.486 ml | 2.431 ml | 4.862 ml |
| 10 mM | 0.243 ml | 1.216 ml | 2.431 ml |
| 5 mM | 0.049 ml | 0.243 ml | 0.486 ml |
Last Update：2024-01-02 23:10:35
6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine - Reference Information
| biological activity | PU-WS13 is a selective Grp94 inhibitor with an EC50 value of 0.22 μM. |
| target | GRP94 0.22 μM (EC 50 ) HSP90α 27.3 μM (EC 50 ) HSP90β 41.8 μM (EC 50 ) TRAP-1 7.3 μM (EC 50 ) |
| in vitro study | PU-WS13 is a Grp94 inhibitor, with an EC 50 of 0.22 μ m. PU-WS13 also slightly suppresses Hsp90α, Hsp90β and Trap-1, with EC 50 s of 27.3, 41.8 and 7.3 μ m, respectively. PU-WS13 (2.5-20 μM) shows no toxicity on two nonmalignant cell lines. PU-WS13 (15 μM) disrupts the circular architecture of HER2 at the plasma membrane of SKBr3 cells mediated through Grp94. PU-WS13 inhibits Grp94, and the inhibition induces apoptosis in and reduce the viability of HER2 overexpressing breast cancer cells. |
Last Update：2024-04-09 21:04:16
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CAS: 1454619-14-7
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Product Name: PU-WS13 Visit Supplier Webpage Request for quotation
CAS: 1454619-14-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1454619-14-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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